Characteristics of TNF-alpha, type I, III collagen, and matrix metalloproteinases. Their clinical applications

Abstract

The world of science, particularly in oncology, continually strives to detect cancer or its recurrence at the earliest possible stage of the disease. Consequently, imaging techniques are constantly refined, while molecular biology is concurrently advancing to understand the mechanisms and pathomechanisms at the cellular level. Immunodiagnostics, which quantitatively determine circulating tumor markers, are also subject to development. Researchers are also attempting to identify markers that enable a fast and accurate diagnosis of diseases with inflammatory, autoimmune, or genetic backgrounds. In this study, we addressed the construction and formation of TNFα, collagen I and II, as well as extracellular matrix metalloproteinases. These molecules also have a significant impact on various processes in the body, including inflammatory and cancer processes. Understanding them in detail allows for a better comprehension of the mechanisms and pathomechanisms of certain diseases. This publication explores their utility in diagnosis and potential treatment approaches for some illnesses. A literature review indicates a consistent increase in interest in these molecules, particularly in certain gastrointestinal, gastric, connective tissue disorders, and central nervous system cancers.