POSSIBLE ASSOCIATION OF POLYMORPHISM CYP2D6 * 4 WITH FREQUENT HOSPITAL STAY OF PATIENTS WITH SCHIZOPHRENIA

  • Tatiana Golubeva
  • Viktor Obyedkov
  • Tatiana Dokukina
  • Yulia Kaminskaya
  • Inna Goloenko
DOI: https://doi.org/10.34668/PJAS.2020.6.2.04

Abstract

The objective of the study was to study the genetic features that affect the metabolic rate of antipsychotics in patients with schizophrenia being frequently (at least once a year) treated in-hospital. The focus of the study was the genetic polymorphism CYP2D6*4 (1846G> A, rs3892097). A significant correlation between the presence of the CYP2D6*4 genetic polymorphism and frequent hospital stay of patients with schizophrenia was found. One of the probable reasons for this correlation may be a poor efficiency of drug therapy due to the slow metabolism of antipsychotics, most of which are the substrates for the CYP2D6 isoenzyme of cytochrome P450.

Published
2021-12-21
How to Cite
GOLUBEVA, Tatiana et al. POSSIBLE ASSOCIATION OF POLYMORPHISM CYP2D6 * 4 WITH FREQUENT HOSPITAL STAY OF PATIENTS WITH SCHIZOPHRENIA. Polish Journal of Applied Sciences, [S.l.], v. 6, n. 2, p. 29-33, dec. 2021. ISSN 2451-1544. Available at: <https://pjas.ansl.edu.pl/index.php/pjas/article/view/172>. Date accessed: 18 apr. 2024. doi: https://doi.org/10.34668/PJAS.2020.6.2.04.
Citation Formats
Issue
Vol 6 No 2 (2020)
Section
Public Health - Subject number - Vol 6 No 2 (2020) Guest Editor Sergei Osipchik

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