POSSIBLE ASSOCIATION OF POLYMORPHISM CYP2D6 * 4 WITH FREQUENT HOSPITAL STAY OF PATIENTS WITH SCHIZOPHRENIA

  • Tatiana Golubeva
  • Viktor Obyedkov
  • Tatiana Dokukina
  • Yulia Kaminskaya
  • Inna Goloenko
DOI: https://doi.org/10.34668/PJAS.2020.6.2.04

Abstract

The objective of the study was to study the genetic features that affect the metabolic rate of antipsychotics in patients with schizophrenia being frequently (at least once a year) treated in-hospital. The focus of the study was the genetic polymorphism CYP2D6*4 (1846G> A, rs3892097). A significant correlation between the presence of the CYP2D6*4 genetic polymorphism and frequent hospital stay of patients with schizophrenia was found. One of the probable reasons for this correlation may be a poor efficiency of drug therapy due to the slow metabolism of antipsychotics, most of which are the substrates for the CYP2D6 isoenzyme of cytochrome P450.

Published
2021-12-21
How to Cite
GOLUBEVA, Tatiana et al. POSSIBLE ASSOCIATION OF POLYMORPHISM CYP2D6 * 4 WITH FREQUENT HOSPITAL STAY OF PATIENTS WITH SCHIZOPHRENIA. Polish Journal of Applied Sciences, [S.l.], v. 6, n. 2, p. 29-33, dec. 2021. ISSN 2451-1544. Available at: <https://pjas.ansl.edu.pl/index.php/pjas/article/view/172>. Date accessed: 21 nov. 2024. doi: https://doi.org/10.34668/PJAS.2020.6.2.04.
Citation Formats
Issue
Vol 6 No 2 (2020)
Section
Public Health - Subject number - Vol 6 No 2 (2020) Guest Editor Sergei Osipchik

The copyright statement must be confirmed with Open Journal Systems.

Author, who submits the paper, bears the main responsibility for given data. „Ghostwriting” and „guest authorship” are the symptoms of scientific dishonesty, and all discovered cases will be exposed, including informing suitable entities. Authors are also required to read the terms of the De Gruyter Open Access License for Open Journal Systems.